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Innovation Pharmaceuticals Inc. (IPIX)·Q2 2017 Earnings Summary

Executive Summary

  • Development-stage biopharma with no product revenue; Q2 FY2017 net loss was $3.36M ($0.03 loss per share), broadly flat year over year; quarter-end cash was $3.86M, with ~$19M remaining under the Aspire Capital equity purchase agreement, supporting near-term liquidity .
  • Pipeline momentum across Brilacidin (oral mucositis and UP/UPS), Prurisol (psoriasis), and Kevetrin (ovarian cancer); management emphasized active partnership discussions under CDAs and near-term clinical readouts as 2017 catalysts .
  • Post-quarter catalyst: Interim Brilacidin OM analysis showed severe OM incidence of 22.2% in Brilacidin vs 70.0% placebo (n=19 evaluable), with favorable tolerability—an upside surprise that could drive partner interest and stock sentiment .
  • No formal financial guidance; company reiterated focus on clinical milestones and partnering rather than near-term revenue, implying shares may trade on clinical data cadence and financing updates .

What Went Well and What Went Wrong

What Went Well

  • Strong interim efficacy signal in Brilacidin OM: severe OM markedly reduced in active vs placebo; CMO: “These interim results suggest the potential for an even greater effective therapeutic response…” highlighting Fast Track designation and preventative potential .
  • Brilacidin UP/UPS Phase 2a cohort showed meaningful symptom improvements with no measurable systemic absorption, supporting localized safety profile and broader anti-inflammatory potential .
  • Prurisol Phase 2b recruitment underway (≈189 patients; higher-dose arms 300mg/400mg); prior Phase 2a data supported moving up the dose range and focusing on moderate–severe plaque psoriasis .

What Went Wrong

  • Continued operating losses with rising R&D: Q2 FY2017 operating expenses $3.31M vs $3.27M YoY; net loss rose slightly to $3.36M; cash declined to $3.86M vs $6.31M at prior fiscal year-end, increasing reliance on external equity financing .
  • Working capital deficit (~$4.6M) and planned ~$19M 12‑month spend (≈$15M clinical) underscore financing/dilution risk absent near-term partnering cash inflows .
  • Accrual accuracy issue: R&D vendor upfront fee accrual reversed ($593k) in Q2, reflecting prior estimate error—while helpful to income, it flags process controls around vendor billing .

Financial Results

MetricQ2 FY2016 (Dec 31, 2015)Q1 FY2017 (Sep 30, 2016)Q2 FY2017 (Dec 31, 2016)
Revenue ($USD)$0 $0 $0
Net Loss ($USD)$(3.32)M $(3.00)M $(3.36)M
Diluted EPS ($USD)$(0.03) $(0.02) $(0.03)
Operating Expenses ($USD)$3.27M N/A$3.31M
Cash and Equivalents ($USD)N/A$5.60M (as of Sep 30, 2016) $3.86M (as of Dec 31, 2016)
Shares Outstanding (Class A)N/A123.59M (Jun 30, 2016) 126.41M (Jan 27, 2017)

Notes:

  • No margins presented given zero revenue; net income margin is not meaningful .
  • Wall Street consensus estimates via S&P Global were unavailable for IPIX due to missing mapping; attempted retrieval but failed (treat estimates as unavailable).

KPIs (expense detail, quarterly):

KPIQ2 FY2016 (Dec 31, 2015)Q2 FY2017 (Dec 31, 2016)
R&D Expenses ($USD)$2.13M $2.68M
G&A Expenses ($USD)$0.35M $0.34M
Professional Fees ($USD)$0.66M $0.15M

Guidance Changes

MetricPeriodPrevious GuidanceCurrent GuidanceChange
Financial Guidance (Revenue, EPS, Margins)FY2017/Q2None providedNone providedMaintained (no guidance)
Brilacidin OM Interim Analysis Timing6–8 weeks from Feb 16, 2017Not previously datedInterim analysis expected in ~6–8 weeksNew timing disclosed
Brilacidin UP/UPS Interim Analysis (Cohort 2)~2 weeks from Feb 16, 2017Not previously datedInterim analysis expected in ~2 weeks; trial completion anticipated 2Q2017New timing disclosed
Kevetrin Phase 2a Start (Ovarian CA)1Q2017PlannedCommenced (Reg FD update)Transition to active status

Earnings Call Themes & Trends

TopicPrevious Mentions (Q1 FY2017 and prior)Current Period (Q2 FY2017)Trend
Partnerships under CDAsHighlighted partner interest and meetings; aim to fund later-stage trials through upfronts/milestones Emphasized focus on partnerships in 2017 with active CDA engagements Strengthening partner focus
R&D execution cadencePrurisol Phase 2b enrollment underway; Brilacidin UP/UPS initial cohort positive; OM interim planned 1H17 Specific interim timelines for OM and UP/UPS; added OM clinical sites; Kevetrin Phase 2a commenced Accelerating readouts
Regulatory designationsABSSSI: SPA request submitted; Brilacidin OM Fast Track Reiterated Fast Track (OM) and OM prevention potential; QIDP for ABSSSI remained in background Consistent; OM emphasized
Funding/dilution strategyAspire agreement utilization; deferring ABSSSI Phase 3 given ~$30M cost and share price ~$19M Aspire capacity remaining; budget ~$19M next 12 months; partnership financing preferred Funding need persists
Safety profile (UP/UPS)Undetectable plasma levels (<100 ng/mL) in cohort; localized exposure Continued emphasis on localized exposure/no measurable systemic absorption Consistent supportive safety

Note: No formal Q2 FY2017 earnings call transcript was available; Q1 FY2017 was delivered via a pre-recorded video with Q&A release info .

Management Commentary

  • “Success in any one of our mid-phase trials could instantly transform the Company overnight… Cellceutix remains partnership-focused in 2017” — Leo Ehrlich, CEO, emphasizing catalysts and strategic partnering .
  • “These interim [OM] results suggest the potential for an even greater effective therapeutic response as formulation and dosing is further optimized… preventative treatment could lead to an entirely new standard of care” — Arthur P. Bertolino, MD, PhD, MBA, President and CMO .
  • “Each study has a valuable component in demonstrating the robustness and potential of our pipeline… a 2017 with a steady flow of information across all four trials” — Bertolino on multi-asset execution .

Q&A Highlights

  • No Q2 FY2017 earnings call or live Q&A disclosed; prior quarter utilized a pre-recorded video presentation and Q&A for analysts and shareholders (format indicates investor engagement but limited real-time dialogue) .

Estimates Context

  • Wall Street consensus (EPS, revenue) via S&P Global was unavailable for IPIX for Q2 FY2017 due to missing CIQ mapping; estimates could not be retrieved despite attempted access. As a result, comparisons to consensus cannot be made this quarter. Expect sell-side to adjust models primarily around clinical timelines and financing runway rather than near-term P&L [Attempted retrieval; unavailable].

Key Takeaways for Investors

  • Liquidity run-rate: $3.86M cash at quarter-end with ~$19M Aspire capacity; management plans ~$19M spend in 12 months—monitor Aspire draw pace and potential partnering cash to mitigate dilution .
  • Brilacidin OM interim data is a meaningful upside catalyst with preventative potential; further readouts and study completion by year-end could drive partner interest and valuation re-rating .
  • UP/UPS localized safety and symptom improvements support Brilacidin’s anti-inflammatory franchise; expanded indications and dermatology applications may be contemplated if data remain supportive .
  • Prurisol Phase 2b: Interim in 2Q2017 target implies a near-term news flow; efficacy at higher doses could unlock partnering discussions in psoriasis .
  • Kevetrin Phase 2a initiation in ovarian cancer provides a mechanistic p53-pathway read; if biomarker modulation is confirmed, oncology partnering optionality improves .
  • No revenue and persistent operating losses mean shares will trade on data cadence and financing; dilution risk remains unless upfront/milestone funding emerges .
  • Operational controls: The $593k accrual reversal highlights the need to tighten vendor billing processes; watch for clean execution updates in future filings .

Appendix: Additional Data Points

  • Q2 FY2017 cash flow (6 months): Operating cash outflow $(5.25)M; financing inflow $2.92M; net cash decrease $(2.45)M .
  • Share count context: 126.41M Class A outstanding as of Jan 27, 2017; continued equity issuance under Aspire .
  • Lease obligations: ~$380k future minimum payments through 2019 .